After an introduction and an overview of quantum annealing, I describe recent developments in non-traditional protocols to control quantum effects for enhanced performance: (i) non-stoquastic drivers , (ii) spatially inhomogeneous driving of the field , and (iii) reverse annealing . I will show explicit examples in which first-order quantum phase transitions can be avoided by these methods, implying an exponential speedup in comparison with the traditional simple transverse-field driving.
 Y. Seki and H. Nishimori, Phys. Rev. E 85, 05112 (2012), J. Phys. A48, 335301 (2015), B. Seoane and H. Nishimori, J. Phys. A45, 435301 (2012), H. Nishimori and K. Takada, Frontiers in ICT, 4, 2 (2017), M. Ohkuwa and H. Nishimori, J. Phys. Soc. Jpn. 86, 114004 (2017). Y. Susa, J.F. Jadebeck and H. Nishimori, Phys. Rev. A 95, 042321 (2017).
 Y. Susa, Y. Yamashiro, M. Yamamoto and H. Nishimori, J. Phys. Soc. Jpn. 87, 023022 (2018), Susa, Y. Yamashiro, M. Yamamoto, I. Hen, D.A. Lidar and H. Nishimori, Phys. Rev. A 98, 042326 (2018)
 M. Ohkuwa, H. Nishimori, and D.A. Lidar, Phys. Rev. A 98, 022314 (2018).