Santa Cruz is easily accessible (within 2 hours drive) of a number of major international airports (below), and is a straightforward drive or shuttle ride from each.
San Jose International Airport (SJC) - https://www.flysanjose.com/
San Francisco International Airport (SFO) - https://www.flysfo.com/
Oakland International Airport (OAK) - https://www.oaklandairport.com/
Shuttle buses will be organized at fixed times from both SJC and SFO. More details on transport to/from the major area airports will be coming soon.